Inspiolto®

COMBINATIONS (DUO)

LONG-ACTING MUSCARINIC ANTAGONIST + LONG-ACTING BETA-2 AGONIST (LAMA + LABA)

  • Class

    • Long-acting muscarinic antagonist (LAMA)
      Long-acting beta-2 agonist (LABA)

  • Active ingredient

    • Tiotropium (as bromide)


    • Olodaterol (as hydrochloride)

  • Device

  • Age

    • 18 +
  • Typical use

    • Asthma (off-label)
      in addition to an ICS, when uncontrolled on high dose ICS + LABA

    Asthma management principles
    • COPD
      uncontrolled on 1 bronchodilator (LAMA or LABA)

    COPD management principles
  • Marketed strength

    • 2.5/2.5 mcg
  • Number of doses

    • 60 doses
  • Dose indicator

    • Yes | Indicator
  • Usual adult dosage

    • 2 inh QD

  • Usual pediatric dosage

    • -

  • Required inspiratory flow

    • < 30 L/min
      Zero internal resistance (R0)

    Inspiratory flows
  • Public coverage

    •  MN – NIHB | Open/Regular Benefit
      All provinces except MN – NIHB | Restricted Benefit with criteria

    Provincial coverage criteria
  • Advantages

    • Suitable for low inspiratory flows
    • Impossible to take empty (locking mechanism)
    • Can be used with a spacer
  • Disadvantages

    • Cartridge insertion difficult
    • Base turn for loading difficult
    • Risk of spraying the face if cap opened before rotating the base
    • Occasional cough without spacer
    • Synchronism required
    Side effects

Product monograph

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