Trelegy®

COMBINATIONS (TRIO)

INHALED CORTICOSTEROID + LONG-ACTING MUSCARINIC ANTAGONIST + LONG-ACTING BETA-2 AGONIST (ICS + LAMA + LABA)

  • Class

    • Inhaled corticosteroid (ICS)
      Long-acting muscarinic antagonist (LAMA)
      Long-acting beta-2 agonist (LABA)

  • Active ingredient

    • Fluticasone furoate


    • Umeclidinium (as bromide)


    • Vilanterol (as trifenatate)

  • Device

  • Age

    • 18 +
  • Typical use

    • Asthma
      uncontrolled on high doses ICS + LABA

    Asthma management principles
    • COPD (100/62.5/25 mcg only)
      exacerbation on dual bronchodilation (LAMA/LABA)

    COPD management principles
  • Marketed strength

    • 100/62,5/25 mcg
    • 200/62,5/25 mcg
  • Number of doses

    • 30 doses
  • Dose indicator

    • Yes | Numerical
  • Usual adult dosage

    • Medium | 100/62.5/25 mcg – 1 inh QD
      High | 200/62.5/25 mcg – 1 inh QD

    ICS dosing
  • Usual pediatric dosage

    • -

  • Required inspiratory flow

    • > 30 - 60 L/min
      Medium-low internal resistance (R2)

    Inspiratory flows
  • Public coverage

    • 100/62.5/25 mcg | All provinces | Restricted Benefit with criteria
      200/62.5/25 mcg | All provinces | Not a Benefit

    Provincial coverage criteria
  • Advantages

    • Once daily dosing
    • All the daily medication in one inhaler
    • Easy handling
  • Disadvantages

    • More dysphonia
    • Taste that can be unpleasant
    • Lip sealing difficult for some older patients
    Side effects

Product monograph

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